Alexander S. Krupnick, M.D.

Cardiothoracic Surgery
Assistant Professor of Surgery
Section of General Thoracic Surgery
Division of Cardiothoracic Surgery

Board Certification:
General Surgery -- Certified
Thoracic Surgery -- Certified

Areas of Clinical Interest:
Thoracic oncology, minimally invasive thoracic surgery, lung transplantation, immunotherapy.

Medical School:
M.D., The University of Michigan Medical School, Ann Arbor, Michigan, 1996.

Postdoctoral Education:
Intern in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1996-1997

Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1997-1999

Surgical Research Fellow, Harrison’s Department of Surgical Research, Hospital of The University of Pennsylvania, 1999-2002

Resident in Surgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 2002-2004

Thoracic Transplant Fellow, Washington University in St. Louis, 2004-2005

Thoracic Surgery Fellow, Barnes-Jewish Hospital, Washington University in St. Louis, 2005-2007

Patients Seen At:
Center for Advanced Medicine
Jacqueline Maritz Lung Center
4921 Parkview Place, Suite B, Floor 8
St. Louis, MO 63110
(314) 454-7280

Barnes-Jewish West County Hospital
Professional Office Building One
1040 North Mason Road, 201
St. Louis, MO 63141
((314) 996-3179

Selected or Recent Publications:
Okazaki M, Kreisel F, Richardson SB, Kreisel D, Krupnick AS, Patterson GA, Gelman AE. Sphingosine 1-phosphate inhibits ischemia reperfusion injury following experimental lung transplantation. America Journal of Transplantation. 2007;7(4):751-758.

Kreisel D, Arora N, Weisenberg SA, Saqi A, Krupnick AS, Demetriades AM, Iakovou C, Conetta R, Lee PC. Tuberculosis presenting as an endobronchial mass. Journal of Thoracic and Cardiovascular Surgery. 2007;133(2):582-584.

Krupnick AS, Gelman AE, Barchet W, Richardson S, Kreisel FH, Turka LA, Colonna M, Patterson GA, Kreisel D. Murine vascular endothelium activates and induces the generation of allogeneic CD4+25+Foxp3+ regulatory T cells. Journal of Immunology. 2005;175(10):6265-6270.

Krupnick AS, Kreisel D, Hope A, Bradley J, Govindan R, Meyers B. Recent advances and future perspectives in the management of lung cancer. Current Problems in Surgery. 2005;42(8):540-610.

Kreisel D, Krupnick AS, Huddleston CB. Outcomes and late complications after pulmonary resections in the pediatric population. Seminars in Thoracic and Cardiovascular Surgery. 2004;16(3):215-219.

Kreisel D, Krasinskas AM, Krupnick AS, Popma SH, Szeto WY, Wu Z, Rosengard AM, Turka LA, Rosengard BR. Vascular endothelium does not activate CD4+ direct allorecognition in graft rejection. Journal of Immunology. 2004;173(5):3027-3034.

Krupnick AS, Balsara KR, Kreisel D, Riha M, Estives MS, Gelman AE, Amin KM, Rosengard BR, Flake AW. Fetal liver as a source of multilineage progenitor cells for perinatal tissue engineering. Tissue Engineering. 2004;10(5/6):723-735.

Krupnick AS, Lombardi JV, Engels FH, Kreisel DK, Zhuang H, Alavi A, Carpenter JP. 18-Fluorodeoxyglucose positron emission tomography as a novel imaging tool for the diagnosis of aorto-enteric fistula and aortic graft infection. Vascular and Endovascular Surgery. 2003;37(5):363-366.

Krupnick AS, Kreisel D, Riha M, Balsara K, Rosengard BR. Tissue engineering and regeneration as a therapeutic alternative to transplantation. Current Topics in Microbiology and Immunology. 2003;280:139-165.

Krupnick AS, Zhu Z, Nguyen T, Kreisel D, Balsara KR, Lankford EB, Clark C, Levine S, Stedman H, Shrager J. Increased diaphragmatic loading by tracheal banding does not accelerate progression of muscular dystrophy in the mdx mouse: implications for regenerative therapy. Journal of Applied Physiology. 2003;94(2):411-419.

Riha M, Krupnick AS, Kreisel D, Rosengard BR. Recent developments in myoblast transplantation and myocardial tissue engineering. Literature Scan: Transplantation. 2002;18(2):5-6.

Kreisel D, Krupnick AS, Balsara KR, Riha M, Szeto WY, Popma SH, Amin KM, Turka LA, Rosengard BR. Mouse vascular endothelium activates CD8+ T lymphocytes in a B7-dependent fashion. Journal of Immunology. 2002;169:6154-6161.

Krupnick AS, Kreisel D, Popma SH, Balsara KR, Szeto WY, Riha M, Wells AS, Turka LA, Rosengard BR. Mechanism of T-cell mediated endothelial apoptosis. Transplantation. 2002;74(6):871-876.

Kreisel D, Petrowski H, Krasinskas AM, Krupnick AS, Szeto WY, Popma SH, McLean AD, Moore JS, Rosengard BR. The role of passenger leukocyte genotype in rejection and acceptance of rat liver allografts. Transplantation. 2002;73(9):1501-1507.

Szeto WY, Krasinskas AM, Kreisel D, Krupnick AS, Popma SH, Rosengard BR. Depletion of recipient CD4+ but not CD8+ T lymphocytes prevents the development of cardiac allograft vasculopathy. Transplantation. 2002;73(7):1116-1122.

Pub Med page for Alexander S. Krupnick, M.D.

Selected or Recent Chapters:
Adzick NS, Krupnick AS. Surgery in the Pregnant Patient. In: Greenfield LJ, Mulholland M, Oldham KT, Zelenock GB, and Lillemoe KD (eds.). Surgery: Scientific Principles and Practice. 4th edition. Philadelphia: Lippincott Williams and Wilkins; 2005.

Krupnick AS, Shrager JB. The Mediastinum. In: Chang, Ganz, Hayes, Kinsella, Pass, Schiller, Stone and Strecher (eds.). Oncology: An Evidence-Based Approach. New York: Springer-Verlag; Chapter 44 (in press, 2004).

Krupnick AS, Adzick NS. Principles of Wound Healing. In Kreisel D, Krupnick AS, Kaiser LR (eds.). The Surgical Review: a Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000: Chapter 6, pp. 110-122.

Krupnick AS, Adzick NS. Burn Injury and Management. In: Kreisel D, Krupnick AS, Kaiser LR (eds.). The Surgical Review: A Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000: Chapter 7, pp. 123-138.

Adzick NS, Krupnick AS. Surgery in the Pregnant Patient. In: Greenfield LJ, Mulholland M, Oldham KT, Zelenock GB, and Lillemoe KD (eds.). Surgery: Scientific Principles and Practice. 3rd edition. Philadelphia: Lippincott Williams and Wilkins; 2001: Chapter 104.

Krupnick AS, Adzick NS. Research in Fetal Surgery. In: Souba W, Wilmore D (eds.). Surgical Research. Academic Press; 2001: Chapter 76, pp. 1065-1079.

Books:
Kreisel D, Krupnick AS, Kaiser LR (editors). The Surgical Review: a Comprehensive Clinical and Basic Science Study Guide. Philadelphia: Lippincott, Williams & Wilkins; 2000.

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